Demet Unsal Selected Research

Syk Kinase

1/2019	NF-κB activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock.
1/2018	The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock.

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Demet Unsal Research Topics

Disease

8	Hypotension (Low Blood Pressure) 01/2019 - 01/2012
7	Septic Shock (Toxic Shock Syndrome) 01/2019 - 01/2012
7	Inflammation (Inflammations) 01/2019 - 01/2012
3	Tachycardia (Tachyarrhythmias) 09/2014 - 04/2013
2	Shock 01/2019 - 01/2012
2	Necrosis 01/2019 - 01/2018
1	Mycoses (Diseases, Fungus) 01/2018
1	Ischemia 01/2014
1	Endotoxemia 07/2013
1	Multiple Organ Failure (MODS) 01/2012
1	Sepsis (Septicemia) 01/2012

Drug/Important Bio-Agent (IBA)

5	LipopolysaccharidesIBA 01/2019 - 01/2012
5	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 09/2014 - 01/2012
4	Vasodilator Agents (Vasodilators)IBA 01/2019 - 01/2012
3	Glycine (Aminoacetic Acid)FDA LinkGeneric 09/2014 - 01/2012
3	N-(20-hydroxyeicosa-5,14-dienoyl)glycineIBA 09/2014 - 04/2013
3	Peroxynitrous Acid (Peroxynitrite)IBA 01/2014 - 07/2013
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2019 - 01/2018
2	2- (7- (3,4- dimethoxyphenyl)imidazo(1,2- c)pyrimidin- 5- ylamino)nicotinamideIBA 01/2019 - 01/2018
2	Syk KinaseIBA 01/2019 - 01/2018
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2019 - 01/2012
2	ZymosanIBA 01/2019 - 01/2018
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2018 - 01/2012
2	EnzymesIBA 01/2018 - 09/2013
2	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 01/2014 - 09/2013
2	EicosanoidsIBA 07/2013 - 01/2012
2	ProstaglandinsIBA 07/2013 - 01/2012
2	CytokinesIBA 04/2013 - 01/2012
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2012 - 01/2012
1	Interleukin-8 (Interleukin 8)IBA 01/2019
1	Peroxidase (Myeloperoxidase)IBA 01/2018
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2018
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018
1	Transforming Growth Factors (Transforming Growth Factor)IBA 09/2014
1	Circulating MicroRNAIBA 09/2014
1	Phosphotransferases (Kinase)IBA 09/2014
1	Myeloid Differentiation Factor 88IBA 09/2014
1	Monomeric GTP-Binding ProteinsIBA 01/2014
1	rho-Associated KinasesIBA 01/2014
1	Soluble Guanylyl CyclaseIBA 09/2013
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 09/2013
1	Superoxides (Superoxide)IBA 09/2013
1	Proteins (Proteins, Gene)FDA Link 07/2013
1	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 07/2013
1	Dinoprostone (PGE2)FDA Link 07/2013
1	Epoxide HydrolasesIBA 04/2013
1	EndotoxinsIBA 01/2012
1	Oxygen (Dioxygen)IBA 01/2012
1	NitrogenIBA 01/2012
1	Lipid AIBA 01/2012
1	Hydroxyeicosatetraenoic Acids (HETE)IBA 01/2012

Therapy/Procedure

2	Controlled Hypotension 01/2019 - 01/2012
1	Resuscitation 01/2012